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A fast, lock-free approach for efficient parallel counting of occurrences of k-mers.

Identifieur interne : 002486 ( Main/Exploration ); précédent : 002485; suivant : 002487

A fast, lock-free approach for efficient parallel counting of occurrences of k-mers.

Auteurs : Guillaume Marçais [États-Unis] ; Carl Kingsford

Source :

RBID : pubmed:21217122

Descripteurs français

English descriptors

Abstract

Counting the number of occurrences of every k-mer (substring of length k) in a long string is a central subproblem in many applications, including genome assembly, error correction of sequencing reads, fast multiple sequence alignment and repeat detection. Recently, the deep sequence coverage generated by next-generation sequencing technologies has caused the amount of sequence to be processed during a genome project to grow rapidly, and has rendered current k-mer counting tools too slow and memory intensive. At the same time, large multicore computers have become commonplace in research facilities allowing for a new parallel computational paradigm.

DOI: 10.1093/bioinformatics/btr011
PubMed: 21217122


Affiliations:


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